The Latin American Commission on Drugs and Democracy released a report ("Drugs and Democracy: Toward a Paradigm Shift") outlining their recommendations about the "drug war." Here is the web site, but unfortunately right now the link to the report does not work.
However, press reports (e.g. the WSJ) provide the gist, namely that the supply emphasis is not working and that drug use is not decreasing. Further, it opens up the idea of decriminalization, at least of marijuana.
The potential importance and influence of this report and its ideas stems from the authors. The commission was headed by Fernando Henrique Cardoso, Ernesto Zedillo, and César Gaviria. They are people the U.S. government gets along with and takes seriously. Having Latin American leaders from the center-right given even more weight to the argument.
Further, this is a regional response. It would have been even better to include a president from Central America to make the symbolic point. The overall point, though, is that regional consensus is quite strong and now is transcending ideological divides, since the left has been saying these sorts of things for a long time.
Obviously, this doesn't necessarily translate into any change in U.S. policy. But at the very least it is a more unified response than usual, and will be hard to ignore.
“It makes no sense to continue a policy on moral grounds without getting the desired results,” said Gaviria, citing an October report by the U.S. Government Accountability Office showing drug reduction goals in Colombia have not been met. “Obama, being a pragmatist, should recognize these failures.”